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PNAS Published Online a Research Paper of Prof. Zhang Yings Team

Date2018-01-02 | Visitcount1868

In January 2, 2018, PNAS (Proceedings of the National Academy of Sciences) published online a paper entitled The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimers disease, which is a cooperative research achievement of Dr. Ye Keqiang, a tenured professor of Emory University, and a BEFS research team led by Prof. Zhang Ying. The research synthesized the prodrug R13 through a specific chemical modification of the active site of 7, 8-dihydroxyflavone, in order to improve the oral bioavailability and the brain exposure level, and elucidated the molecular mechanism of its treatment of Alzheimer disease.

The papers first author is Zhang Chun, a Ph.D student of Prof. Zhang Ying; the corresponding author is Prof. Ye Keqiang of Emory University. This is the first time that BEFS has ever published a research paper on PNAS.

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